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Here, we are working to understand the effect of granulation process parameters on granule content uniformity and dissolution and its subsequent effect on tablet properties (microstructure and dissolution).  We are aiming to decouple the effects of segregation, preferential wetting and drug migration to be able to design and engineer optimal granules to influence and obtain quality tablets with desired properties.

Improper Mixing

Effect of Improper mixing: Visualization of pores in control volume

NIR Monitoring

NIR Monitoring of Mulling Processes: 15 mm different distance spectra from 9 -21 mm with 1.5 mm interval

Micro-CT Study

Micro-CT Study of Dissolution: Evolution of the dissolution front in sample during 24 hrs (the arrows indicate the initial positions of several large API crystals)